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KMID : 0895820050150040117
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Journal of Oriental Rehabilitation Medicine
2005 Volume.15 No. 4 p.117 ~ p.129
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Study of Immunom odulatory Effect of Gwanjulbang-1 (Quanjiefang-1 ) on Rheumatoid Arthritis
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Han Kyu-Jin
Jin Kwang-Seon
Shin Hye-Ran
Yoon Il-Ji
Choi Seung-Hoon
Oh Min-Seok
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Abstract
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Objectives: The aim of this study was to know the immunity responses of Gwanjulbang-1(Quanjiefang-1)(hereinafter referred to GJB-1) to on Rheumatoid Arthritis in Collagen-induced Arthritis(CIA) Mice.
Methods: For this purpose, experiments were performed to measure the cytotoxicity against mLFC, hFLSs and the production of proinflammatory cytokines IL-1β, IL-6, TNF-α, IFN-γ in hFLSs and the production of pro-inflammatory cytokines IL-4, IL-10 and the value of CD3+(T), CD19+(B), CD3+/CD69+, CD4, γδ T cells, CD4+/CD25+
Results:
1. The cytotoxicity against mLFC, hFLSs were not measured.
2. The production of pro-inflammatory cytokines IFN-γ were reduced in hFLSs.
3. The production of pro-inflammatory cytokines IL-4, IL-10 were increased.
4. Statistically significant value of CD3+(T), CD19+(B), CD3+/CD69+, CD4, γδ T cells, CD4+/CD25+ compared with control group, wild type, MTX.
Conclusions: Comparison of the results for this study showed that GJB-1 had immunomodulatory effects of suppressing or enhancing. So we expect that GJB-1 should be used as a effective drugs for not only rheumatoid arthritis but also another auto-immune disease. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.
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KEYWORD
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Gwanjulbang-1(Quanjiefang-1), Rheumatoid arthritis, Immunomodulatory, Immunity, Collagen-induced arthritis(CIA) mice
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